Figure 5. Identification of mouse NK-22 cells.

a, In vitro stimulation of Peyer’s patches cells with IL-23 induces production of IL-22 by NKp46⁺ NK cells. A gate was applied to exclude CD3⁺CD19⁺ cells; b, NKp46⁺ IL-22-producing cells are in part NK1.1⁻ and, to a lower degree, NK1.1⁺. c, NK-22 cell appear in the small intestine lamina propria of C. rodentium-infected mice. A large proportion (55-80% in different experiments) of cells producing IL-22 in the lamina propria express NKp46.