Table 3.

Regions of Activation in Comparisons of Negative to Neutral Stimuli: Between-Group Contrasts

Contrast	Region of Interest (ROI)		x	y	za	Z	Voxels	Uncorrected p-valueb	Voxel-level FWE-corrected p-valuec	Effect sized
rMDD > HC
	Hypothalamus	R	9	−7	−14	2.34	13	0.010	0.095	0.86
	Amygdala	R	18	−1	−29	2.43	24	0.008	0.119	0.90
	Amygdala	L	−30	−7	−23	2.84	36	0.002	0.048	1.11
	Hippocampus	R	36	−19	−14	2.99	84	0.001	0.072	1.29
	Hippocampus	L	−18	−13	−20	3.44	101	0.000	0.023	1.33
	Anterior Cingulate Cortex	R	6	8	28	3.34	162	0.000	0.089	1.27
	Subgenual ACC	L	−3	17	−11	2.38	9	0.009	0.145	0.85
HC > rMDD
	none

^aCoordinates are presented in MNI space.

^bWithin an anatomic ROI, results identified using small volume correction with voxel-wise peak-level height threshold: p<0.05, uncorrected for multiple comparisons.

^cFalse positives controlled using family-wise error (FWE) correction. Results are reported (in bold) as significant if they additionally met the peak-level threshold of p<0.05, FWE-corrected.

^dEffect sizes based on average percent signal change values (beta weights averaged across 4mm radius spheres for amygdala and hypothalamus and 6mm radius spheres for other regions, drawn around the maximum voxel of difference within an anatomical ROI) were obtained using the REX toolbox for SPM8.