Appendix Table 3.

CAD Use and Breast Cancer Diagnostic Testing Among Women Without Breast Cancer, Stratified by Mammography Use in the Previous 24 Months and Whether Previous Mammography Was CAD or Non-CAD^*

Diagnostic Test, by Previous Mammography Stratum	Non-CAD, n (unadjusted %)	CAD, n (unadjusted %)	Adjusted OR (95% CI)†	P Value
Non-CAD mammography in previous 9–24 mo (n = 222 861)
Diagnostic mammography	10 122 (5.39)	2720 (7.19)	1.32 (1.31–1.34)	<0.001
Breast ultrasonography	6476 (3.45)	1446 (3.82)	1.14 (1.12–1.16)	<0.001
Either diagnostic mammography or breast ultrasonography	12 906 (6.88)	3202 (8.47)	1.25 (1.24–1.27)	<0.001
Breast biopsy	2259 (1.20)	533 (1.41)	1.22 (1.18–1.25)	<0.001
CAD mammography in previous 9–24 mo (n = 56 700)
Diagnostic mammography	197 (5.89)	3412 (6.32)	1.13 (1.08–1.18)	<0.001
Breast ultrasonography	124 (3.71)	1711 (3.17)	0.85 (0.81–0.90)	<0.001
Either diagnostic mammography or breast ultrasonography	250 (7.47)	3899 (7.22)	1.01 (0.97–1.04)	0.80
Breast biopsy	45 (1.34)	601 (1.11)	0.82 (0.76–0.90)	<0.001
No previous mammography in the past 24 mo or previous mammography >24 mo (n = 89 795)
Diagnostic mammography	4834 (7.06)	1889 (8.44)	1.20 (1.18–1.22)	<0.001
Breast ultrasonography	3290 (4.81)	1124 (5.02)	1.02 (1.00–1.04)	0.093
Either diagnostic mammography or breast ultrasonography	6202 (9.06)	2240 (10.01)	1.12 (1.10–1.13)	<0.001
Breast biopsy	4834 (7.06)	1889 (8.44)	1.07 (1.03–1.11)	<0.001

CAD = computer-aided detection; OR = odds ratio.

^*Based on 369 356 mammograms from 116 738 women.

^†Adjusted for age, race or ethnicity, rural vs. urban residence, median income of elderly residents within the same ZIP code, presence of stable and unstable comorbid conditions, digital vs. film mammography, year of examination, SEER (Surveillance, Epidemiology and End Results) region, and a radiologist-level random effect. Owing to missing covariate data, adjusted analyses include 337 753 mammograms from 99 540 women.