Table 3.

Mean cortical thickness for clusters within individual parcellation units (PUs). Test statistics show the group effect after controlling for average thickness of the entire neocortex. The RWR network is comprised of five regions (DLPFC, CGa, FOC, INS, PAC), sub-divided by the parcellation schema. There are 26 distinct parcellation units for post-hoc analyses outside of RWR. The overall multivariate general linear mixed model for RWR units, covarying for average cortical thickness, shows F(5, 40) = 6.3, p < 0.001.

				Means		Std Devs.		Cluster statistic
Region	# vertices in the cluster	# vertices in the PU	%PU	Controls	Addicts	Controls	Addicts	T value	P-value
Right RWR
F1l	754	2189	34.4	3.75	3.43	0.38	0.26	3.1	0.004 *
F2	1810	3362	53.8	3.42	3.12	0.28	0.21	4.0	<0.001 *
subgenual_CGa_BA24_32	0	334	.	.	.	.	.	.	.
pregenual_CGa_BA24	0	882	.	.	.	.	.	.	.
amCGa_BA24	0	1262	.	.	.	.	.	.	.
aFOC	0	268	.	.	.	.	.	.	.
pFOC	15	646	2.3	4.64	4.32	0.52	0.42	.	.
mFOC	4	494	0.8	4.59	4.27	0.52	0.42	.	.
lFOC	0	294	.	.	.	.	.	.	.
aINS	245	1365	17.9	4.31	4.04	0.34	0.26	2.7	0.009 *
pINS	264	1188	22.2	3.57	3.24	0.46	0.30	2.8	0.008 *
PAC_BA32_dorsal	0	358	.	.	.	.	.	.	.
pregenual_PAC_BA32	249	980	25.4	4.52	4.14	0.48	0.44	2.5	0.02
Other Right Hemisphere Regions
AG	133	1562	8.5	3.70	3.36	0.51	0.33	2.35	0.0244
COa	124	585	21.2	3.79	3.56	0.32	0.27	2.33	0.0253
F1m	94	993	9.5	4.46	4.16	0.45	0.36	2.17	0.0366
F3o	203	629	32.3	3.47	3.22	0.24	0.24	3.27	0.0023
FMC	112	431	26.0	4.58	4.18	0.52	0.50	2.29	0.0277
FO	184	699	26.3	3.91	3.70	0.25	0.24	2.49	0.0172
FP	113	4281	2.6	4.34	4.01	0.43	0.40	2.32	0.0262
LG	142	1677	8.5	2.59	2.85	0.27	0.32	−2.81	0.0078
PO	64	513	12.5	3.34	3.10	0.34	0.30	2.06	0.0469
PRG_inf	278	1854	15.0	3.33	3.07	0.25	0.22	3.45	0.0014 **
PRG_mid	284	1425	19.9	2.85	2.56	0.37	0.23	2.79	0.0083
Other Left Hemiphere Regions
AG	137	1264	10.8	3.66	3.97	0.39	0.27	−3.34	0.0019 **
aINS	180	1366	13.2	4.87	4.48	0.39	0.42	2.82	0.0076
BFsbcmp	157	944	16.6	1.59	2.19	0.48	0.72	−3.18	0.0030
F1l	119	2118	5.6	4.11	3.86	0.32	0.20	3.15	0.0032
F1m	101	1132	8.9	4.25	4.02	0.31	0.23	2.67	0.0111
F2	92	3652	2.5	3.94	3.66	0.42	0.28	2.32	0.0260
FP	206	4829	4.3	4.03	3.71	0.45	0.26	2.98	0.0050
OLs	62	1773	3.5	3.80	4.08	0.37	0.35	−3.43	0.0015 **
PCN	78	2233	3.5	3.27	3.54	0.37	0.34	−2.86	0.0070
pFOC	62	506	12.3	4.68	4.31	0.37	0.57	2.21	0.0337
POG_inf	156	2139	7.3	3.45	3.23	0.21	0.25	2.92	0.0059
POG_med	149	874	17.0	3.82	3.45	0.47	0.43	2.47	0.0183
SGp	100	2074	4.8	3.75	3.47	0.42	0.29	2.22	0.0323
SPL	65	1436	4.5	3.63	3.31	0.51	0.39	2.10	0.0429
TOF	75	926	8.1	3.30	3.57	0.25	0.46	−2.76	0.0089

^*indicates a significant difference at alpha (0.05) corrected for 5 comparisons = 0.01, and

^**indicates a significant difference at alpha (0.05) corrected for 26 comparisons = 0.0019. Abbreviations: RWR: reward regulation system; BA: Brodmann’s area; F1l: superior fronal gyrus lateral division; F2: middle frontal gyrus; CGa: anterior cingulate gyrus; amCGa: anterior cingulate gyrus, anterior middle division; aFOC, pFOC, mFOC, lFOC: anterior, posterior, medial, lateral fronto-orbital cortex; aINS: anterior insula; pINS: posterior insula; PAC: paracingulate gyrus; AG: angular gyrus; COa: anterior central opercular cortex; F1m: medial superior frontal gyrus; F3o: inferior frontal gyrus, pars opercularis; FMC: frontal medial cortex; FO: frontal operculum cortex; FP: frontal pole; LG: lingual gyrus; PO: parietal operculum cortex; PRG_inf: precentral gyrus inferior division; PRG_mid: precentral gyrus middle division; BFsbcmp: basal forebrain subcomponent; OLs: superior lateral occipital cortex; PCN: precuneus cortex; POG_inf: postcentral gyrus, inferior division; POG_med: postcentral gyrus, medial division; SGp: posterior supramarginal gyrus; SPL: superior parietal lobule; TOF: temporal occipital fusiform cortex.