Table 2.
Pharmacokinetic parameters of CMS and formed colistin in rats (n = 4)
| Parameters | X-GEN (USA) | Paddock (USA) | Atlantic (Thailand) | Forest (UK) |
|---|---|---|---|---|
| CMS | ||||
| CL (mL/min/kg) | 8.30 ± 1.50 | 8.35 ± 1.05 | 8.33 ± 0.75 | 9.13 ± 0.49 |
| Vz (L/kg) | 0.36 ± 0.11 | 0.31 ± 0.014 | 0.34 ± 0.046 | 0.29 ± 0.010 |
| t1/2 (min) | 29.2 ± 4.24 | 25.9 ± 2.45 | 28.4 ± 4.75 | 21.9 ± 1.02 |
| AUC0–180min (mg·min/L) | 3429 ± 642 | 3371 ± 375 | 3336 ± 293 | 3026 ± 170 |
| Formed colistin | ||||
| t1/2 (min)a | 108.0 ± 57.2 | 68.9 ± 12.0 | 107.2 ± 13.5 | 45.3 ± 10.0 |
| Cmax (mg/L) | 0.49 ± 0.035 | 0.44 ± 0.10 | 0.62 ± 0.075 | 0.47 ± 0.053 |
| AUC0–180min (mg·min/L) | 65.4 ± 6.81 | 40.5 ± 10.6 | 77.8 ± 9.54 | 42.4 ± 12.0 |
| ratio of AUC0–180min of colistin to CMS (%)b | 2.73 ± 0.41 | 1.68 ± 0.35 | 3.29 ± 0.43 | 1.98 ± 0.58 |
at1/2 of formed colistin was calculated based on the last three timepoints.
bIn molar terms.