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. 2013 Sep 6;6:1249–1259. doi: 10.2147/OTT.S36162

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© 2013 Espinoza et al. This work is published by Dove Medical Press Ltd, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Ltd, provided the work is properly attributed.

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Intercellular interaction between mesenchymal stem cells and breast cancer cells through Notch can activate EMT through N^IC, Hey, HES, and other activators. Mesenchymal stem cells modified with miR-126 release proangiogenic factors and induce expression of proangiogenic Notch ligand DLL 1, 3, 4 and Jagged-1/2 enhancing angiogenesis. Moreover, Notch signaling regulates the expression of CXCR4 in mesenchymal stem cells, modulating their migration.

Abbreviations: DLL, Delta-like; EMT, epithelial-to-mesenchymal transition; Notch-1^IC, Notch-1 intracellular domain; Jag, Jagged; HES, Hairy/Enhancer of Split; Hey, Hairy/enhancer-of-split related with YRPW motif-like protein.