Figure 1.

NF-κB protein family.

Notes: All family members share the RHD, composed of a DNA-binding region and a dimerization region. RELA and c-REL have two TAD whereas RELB contains only one. P100 and p105 precursor proteins are processed by the proteosome to the mature p52 and p50 respectively and lack a transactivation domain. Other indicated domains are: LZ; GRR; DD.

Abbreviations: DD, death domain; DNA, deoxyribonucleic acid; GRR, glycine-rich region; LZ, leucine zipper; NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells; RHD, Rel homology domain; TAD, transactivation domains.