Table 3. Most highly significant associations between DNA methylation and obesity measures.

CpG Site#	Waist Circumference		Body Mass Index (BMI)
	Beta*	P-value	Beta*	P-value
SEPT5_P441_F	−0.238	5.47×10−4	−0.146	3.04×10−2
LMTK2_P1034_F	−0.193	2.84×10−3	−0.117	6.46×10−2
SFTPB_P689_R	−0.203	4.00×10−3	−0.162	1.79×10−2
ARHGAP9_P518_R	−0.180	5.96×10−3	−0.086	1.78×10−1
KRT5_P308_F	−0.187	6.42×10−3	−0.073	2.83×10−1
ZIM2_P22_F	−0.170	8.75×10−3	−0.066	2.97×10−1
PEG3_E496_F	−0.168	9.45×10−3	−0.151	1.62×10−2
CD81_P272_R	−0.173	1.17×10−2	−0.150	2.31×10−2
MEST_P62_R	−0.174	1.29×10−2	−0.137	4.41×10−2
TSP50_E21_R	−0.168	1.50×10−2	−0.059	3.79×10−1

Note: all significance values are nominal.

^#CpG sites are annotated according to GENE_Position_Strand, as outlined in the methods section.

^*A positive value for beta indicates increased methylation is associated with increased obesity measures (i.e. increased waist circumference or increased BMI).