Table 3. Most highly significant associations between DNA methylation and obesity measures.
CpG Site# | Waist Circumference | Body Mass Index (BMI) | ||
Beta* | P-value | Beta* | P-value | |
SEPT5_P441_F | −0.238 | 5.47×10−4 | −0.146 | 3.04×10−2 |
LMTK2_P1034_F | −0.193 | 2.84×10−3 | −0.117 | 6.46×10−2 |
SFTPB_P689_R | −0.203 | 4.00×10−3 | −0.162 | 1.79×10−2 |
ARHGAP9_P518_R | −0.180 | 5.96×10−3 | −0.086 | 1.78×10−1 |
KRT5_P308_F | −0.187 | 6.42×10−3 | −0.073 | 2.83×10−1 |
ZIM2_P22_F | −0.170 | 8.75×10−3 | −0.066 | 2.97×10−1 |
PEG3_E496_F | −0.168 | 9.45×10−3 | −0.151 | 1.62×10−2 |
CD81_P272_R | −0.173 | 1.17×10−2 | −0.150 | 2.31×10−2 |
MEST_P62_R | −0.174 | 1.29×10−2 | −0.137 | 4.41×10−2 |
TSP50_E21_R | −0.168 | 1.50×10−2 | −0.059 | 3.79×10−1 |
Note: all significance values are nominal.
CpG sites are annotated according to GENE_Position_Strand, as outlined in the methods section.
A positive value for beta indicates increased methylation is associated with increased obesity measures (i.e. increased waist circumference or increased BMI).