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. 2013 Sep 13;8(9):e74401. doi: 10.1371/journal.pone.0074401

Figure 1. Effect of MG on platelet aggregation.

Figure 1

Aggregation of washed human platelets treated with either solvent (CTL) or methylglyoxal (MG, 1 mmol/L, 15 minutes) prior to the stimulation with either (a) thrombin or (b) collagen. (c) Thrombin-induced aggregation of platelet rich plasma from healthy (CTL) or diabetic patients (Dia) in the absence or in the presence of solvent or MG. (d) Aggregation of washed human platelets treated with either solvent (CTL), methylglyoxal (MG, 1 mmol/L, 15 minutes) or glycated human serum albumin (G-HAS, 40 and 300 µg, 15 minutes) prior to the stimulation with thrombin. The graphs summarise the data from at least 6 different individuals; *P<0.05, **P<0.01 versus CTL.