Table 3. The top 10 pathways that could be affected by clopidogrel in the GES-1 cells.
Pathway | P-value* | FDR** | Gene involved |
1. ECM-receptor interaction | 0 | 0 | AGRN, COL1A1, COL5A1, LAMA5 |
2. Focal adhesion | 2.00E-04 | 1.00E-04 | COL1A1, COL5A1, LAMA5, VEGFA |
3. MAPK signaling pathway | 6.00E-04 | 2.00E-04 | DDIT3, DUSP10, DUSP2, MYC |
4. Nitrogen metabolism | 6.00E-04 | 2.00E-04 | ASNS, CTH |
5. Alanine, aspartate and glutamatemetabolism | 0.001 | 2.00E-04 | ASNS, GPT2 |
6. Glycine, serine and threonine metabolis | 0.001 | 2.00E-04 | CTH, PSAT1 |
7. Pathways in cancer | 0.0012 | 2.00E-04 | LAMA5, MYC, VEGFA, WNT7B |
8. Bladder cancer | 0.0017 | 3.00E-04 | MYC, VEGFA |
9. p53 signaling pathway | 0.0044 | 5.00E-04 | PMAIP1, SESN2 |
10. Metabolic pathways | 0.0046 | 5.00E-04 | ASNS, CTH, DHRS3, GPT2, PCK2 |
Enrichment P-value of the corresponding pathway as determined by Fisher’s exact test.
FDR of the corresponding pathway.
Bold, up-regulated; non-bold, down-regulated.