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. 2013 Sep 13;8(9):e74381. doi: 10.1371/journal.pone.0074381

Table 3. The top 10 pathways that could be affected by clopidogrel in the GES-1 cells.

Pathway P-value* FDR** Gene involved
1. ECM-receptor interaction 0 0 AGRN, COL1A1, COL5A1, LAMA5
2. Focal adhesion 2.00E-04 1.00E-04 COL1A1, COL5A1, LAMA5, VEGFA
3. MAPK signaling pathway 6.00E-04 2.00E-04 DDIT3, DUSP10, DUSP2, MYC
4. Nitrogen metabolism 6.00E-04 2.00E-04 ASNS, CTH
5. Alanine, aspartate and glutamatemetabolism 0.001 2.00E-04 ASNS, GPT2
6. Glycine, serine and threonine metabolis 0.001 2.00E-04 CTH, PSAT1
7. Pathways in cancer 0.0012 2.00E-04 LAMA5, MYC, VEGFA, WNT7B
8. Bladder cancer 0.0017 3.00E-04 MYC, VEGFA
9. p53 signaling pathway 0.0044 5.00E-04 PMAIP1, SESN2
10. Metabolic pathways 0.0046 5.00E-04 ASNS, CTH, DHRS3, GPT2, PCK2
*

Enrichment P-value of the corresponding pathway as determined by Fisher’s exact test.

**

FDR of the corresponding pathway.

Bold, up-regulated; non-bold, down-regulated.