Databases: Embase, MEDLINE, MEDLINE In-Process and Other Non-Indexed Citations

Search engine: Ovid

Time period: 1989 to October 2012

Search date: October 26th, 2012

1. Tiotropium bromide/or aclidinium bromide/or glycopyrronium bromide/(6235)

2. (Tiotropium or spiriva or aclidinium bromide or Eklira or Glycopyrronium or NVA-237 or NVA237 or (NVA adj “237”) or glycopyrronium bromide or glycopyrrolate).ti,ab. (3378)

3. (COPD or chronic obstructive pulmonary disease or COAD or chronic obstructive airway disease or chronic obstructive lung disease or chronic bronchitis or emphysema).ab. or (COPD or chronic obstructive pulmonary disease or COAD or chronic obstructive airway disease or chronic obstructive lung disease or chronic bronchitis or emphysema).ti. (112741)

4. Exp Pulmonary Disease, Chronic Obstructive/or exp Chronic obstructive lung disease/(74383)

5. (Randomised or randomized or randomly or placebo or trial).ab. or (randomised or randomized or randomly or placebo or trial).ti. (1503026)

6. Exp RANDOMIZED CONTROLLED TRIAL/(654235)

7. Exp controlled clinical trial/(530101)

8. (1 or 2) and (3 or 4) and (5 or 6 or 7) (1004)

9. (Animals not humans).sh. (3705463)

10. 8 not 9 (1004)

11. 10 (1004)

12. Limit 11 to English language (944)

13. Limit 12 to yr = “1989-Current” (944)

14. Remove duplicates from 13 (632)

Database: Cochrane

Search date: October 26th, 2012

1. MeSH descriptor Pulmonary Disease, Chronic Obstructive explode all trees (1834)

2. (COPD or chronic obstructive pulmonary disease or COAD or chronic obstructive airway disease or chronic obstructive lung disease or chronic bronchitis or emphysema) (9973)

3. Tiotropium or spiriva or aclidinium bromide or Eklira or Glycopyrronium or NVA-237 or NVA237 or (NVA adj “237”) or glycopyrronium bromide or glycopyrrolate (953)

4. ((#1 OR #2) AND #3) (520)

5. (#4), from 1989 to 2012 limit to trials (446)

Database: clinicaltrials.gov

Search date: October 26th, 2012

NVA-237 or NVA237 or (NVA adj “237”) or glycopyrronium bromide or glycopyrrolate [INTERVENTION]

AND copd [CONDITION]

AND (“Phase II” OR “Phase III” OR “Phase IV”) [PHASE]

Database: Pubmed

Search date: October 26th, 2012

1. Search tiotropium OR spiriva OR aclidinium bromide OR Eklira OR Glycopyrronium OR NVA-237 OR NVA237 OR glycopyrronium bromide OR glycopyrrolate [Title/Abstract] (1782)

2. Search COPD OR chronic obstructive pulmonary disease OR COAD OR chronic obstructive airway disease OR chronic obstructive lung disease OR chronic bronchitis OR emphysema [Title/Abstract] (65084)

3. Search randomised OR randomized OR randomly OR placebo OR trial [Title/Abstract] (846800)

4. Search ((#3) AND #2) AND #1 (366)

5. Search ((“Glycopyrrolate” [Mesh]) OR “tiotropium” [Supplementary Concept]) OR “(3R)-3-((hydroxy(di-2-thienyl)acetyl)oxy)-1-(3-phenoxypropyl)-1-azoniabicyclo(2.2.2)octane bromide” [Supplementary Concept] Filters: Publication date from 2012/01/01 to 2013/12/31 (55)

6. Search (#4) NOT #5 Filters: Publication date from 2012/01/01 to 2013/12/31 (32)