Table 3. Univariate analysis for Progression Free Survival and Overall Survival.

	ProgressionFreeSurvival			OverallSurvival
	Hazard Ratio	95% CI	p-value			p-value
Limited-StageSCLC(n=64)
ERCC1 expression (High vs Low)	1.71	1.24-2.91	0.01	1.63	1.13-2.27	0.027
PKM2 expression (High vs Low)	1. 64	1.17-2.42	0.031	1.49	1.06-1.84	0.046
TOPOI expression (High vs Low)	1.41	1.26-1.98	0.044	1.37	0.96-1.51	0.106
TOPOIIA expression (High vs Low)	1.74	1.33-3.1	0.009	1.69	1.2-2.34	0.018
TOPOIIB expression (High vs Low)	1.82	1.46-3.18	0.004	1.8	1.43-3.11	0.006
Expression signature (unfavourable vs. favourable)	4.97	2.74-7.61	0.001	5.34	3.85-7.62	<0.001
PS (2 vs. 0-1)	1.46	1.22-2. 81	0.017	1.58	1.29-2.9	0.013
LDH (elevated vs. normal)	1.52	1.21-2.78	0.021	1.56	1.22-2.94	0.027
Extended-StageSCLC(n=120)
TOPOIIB expression (High vs. Low)	1.25	0.89-1.80	0.186	1.53	1.09-1.89	0.046
Expression signature (unfavourable vs. favourable)	3.56	1.89-6.46	0.001	4.14	1.95-6.58	0.001
PS (2 vs. 0-1)	1.81	1.17-2.83	0.023	1.94	1.62-2.58	0.017
LDH (elevated vs. normal)	1.93	1.43–2.94	0.019	2.01	1.61-2.64	0.0.13