Table 1. Select demographics, gene expression and CYP3A activity in study cohort.
| Cirrhosis (n=28) | Normal (n=12) | ||
|---|---|---|---|
| Demographics | |||
| Age, years (mean ± SD) | 57.4 ± 13.7 | 50.5 ± 18.8 | |
| Females (%) | 50 | 42 | |
| Non-Hispanic white (%) | 96 | 100 | |
| BMI kg/m2 (mean ± SD) | 27.6 ± 5.7 | Not available | |
| Diabetes (%) | 46 | Not available | |
| History of smoking (%) | 32 | Not available | |
| Etiology of cirrhosis (%) | |||
| - NASH (n=17) | 61 | N/A | |
| - Cholestatic (n=11) | 39 | N/A | |
| Concomitant HCC (n=5) | 18 | N/A | |
| Relative gene expression (2-ΔΔCt mean ± SEM) | Pvalue | ||
| CYP3A4 mRNA | 21.76 ± 2.65 | 5.91 ± 1.29 | 2.04E-07 |
| PXR mRNA | 6.15 ± 0.45 | 4.45 ± 0.87 | 0.04 |
| CAR mRNA | 6.26 ± 0.43 | 3.55 ± 0.71 | 0.0008 |
| PPARα mRNA | 0.63 ± 0.06 | 0.06 ± 0.01 | 1.90029E-12 |
| CYP3A activity (mL*min-1*mg protein-1) (mean ± SEM) | 0.28 ± 0.06 | 0.47 ± 0.07 | 0.02 |
N/A: not applicable