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Biologically active artificial proteins modeled on the BPV1 E5 protein. The top line shows the sequence of the BPV1 E5 protein. The blue amino acids in the other lines show the randomized transmembrane segment. BPV1 E5 and pTM36-4 activate the PDGF β receptor; TC2-3 activates the human erythropoietin receptor; and BY1PC2 down-regulates the HIV co-receptor, CCR5.
