Table 4.

Results of Linear Mixed Models with Interaction of Age at Baseline with Relationship Status

	Outcomes
	Depression b (SE), p	Anxiety b (SE), p	Health-Related Quality of Life b (SE), p	Breathlessness b (SE), p
Interaction Age x Relationship Status	Overall p = 0.03	Overall p = 0.59	Overall p = 0.02	Overall p < 0.01
Effect of Age if Single	−0.08 (0.03), < 0.01	−0.08 (0.03), 0.02	−0.61 (0.16), < 0.001	−0.023 (0.009), < 0.01
Effect of Age if Coupled	−0.01 (0.02), 0.67	−0.10 (0.02), < 0.001	−0.18 (0.10), 0.07	0.005 (0.005), 0.39
Age at Baselinea	−0.04 (0.02), 0.01	−0.09 (0.02), < 0.001	−0.39 (0.10), < 0.001	−0.009 (0.005), 0.07
Years Since COPD was Diagnosed	0.01 (0.02), 0.53	0.01 (0.02), 0.61	0.37 (0.11), < 0.001	0.023 (0.006), < 0.001
Gender
Male	Reference	Reference	Reference	Reference
Female	0.12 (0.29), 0.67	0.89 (0.34), < 0.01	2.88 (1.57), 0.07	0.124 (0.086), 0.15
Relationship Statusb
Single	Reference	Reference	Reference	Reference
Coupled	−0.25 (0.34), 0.47	−0.53 (0.38), 0.17	−4.66 (1.80), < 0.01	−0.108 (0.098), 0.27
Education	Overall < 0.01	Overall p = 0.06	Overall p < 0.001	Overall p < 0.01
Grade 12 or less	1.24 (0.35), < 0.001	0.97 (0.41), 0.02	7.21 (1.91), < 0.001	0.310 (0.104), < 0.01
College 1 to 3 years	0.66 (0.33), 0.05	0.49 (0.38), 0.20	4.87 (1.80), < 0.01	0.218 (0.098), 0.03
College graduate or more	Reference	Reference	Reference	Reference
Lifetime Tobacco Exposure	Overall p = 0.61	Overall p = 0.71	Overall p = 0.91	Overall p = 0.65
Never smoked	Reference	Reference	Reference	Reference
1 to 20 pack years	0.24 (0.36), 0.49	0.02 (0.41), 0.95	0.01 (1.92), 0.995	0.060 (0.105), 0.57
More than 20 pack years	0.36 (0.37), 0.33	0.30 (0.42), 0.48	0.73 (1.99), 0.71	0.100 (0.109), 0.36
Genotype	Overall p < 0.01	Overall p = 0.12	Overall p < 0.001	Overall p = 0.03
Severely deficient	Reference	Reference	Reference	Reference
Not severely deficient	1.45 (0.57), 0.01	1.08 (0.65), 0.10	8.81 (3.07), < 0.01	−0.131 (0.167), 0.43
Unknown	1.25 (0.50), 0.01	0.90 (0.58), 0.12	8.79 (2.77), < 0.01	0.353 (0.149), 0.02
Oxygen Use
No	Reference	Reference	Reference	Reference
Yes	1.65 (0.29), < 0.001	0.39 (0.34), 0.24	13.56 (1.56), < 0.001	0.978 (0.086), < 0.001
Augmentation Therapy Use
No	Reference	Reference	Reference	Reference
Yes	−0.42 (0.39), 0.27	0.35 (0.44), 0.43	2.42 (2.10), 0.25	−0.101 (0.115), 0.38
Time	Overall p = 0.74	Overall p = 0.07	Overall p = 0.26	Overall p = 0.34
Baseline	−0.11 (0.14), 0.44	0.34 (0.16), 0.03	0.63 (0.61), 0.30	−0.025 (0.043), 0.56
1-year follow-up	−0.05 (0.13), 0.70	0.29 (0.16), 0.07	−0.29 (0.50), 0.56	−0.065 (0.045), 0.15
2-year follow-up	Reference	Reference	Reference	Reference

^aEffect of age, unweighted average over both relationship statuses

^bEffect of relationship status for the average age