Table 1.

Metabolites from young and old mouse skeletal muscle with and without SS-31 treatment.

	YOUNG		OLD
	C	SS31	C	SS31
Body wt (g)	25.20±0.92	24.81±0.48	29.30±0.87*	28.67±0.54
GA wt (mg)	124.4±3.6	123.8±1.1	109.5±3.6*	106.1±4.0
ATP(mM)	10.26±0.29	9.20±0.14	7.98±0.22**	7.69±0.15
PCr(mM)	36.83±1.31	33.36±1.20	24.43±0.75***	29.29±1.89#
Pi(mM)	3.55±0.37	2.31±0.31	2.40±0.23*	2.18±0.22
Cr(mM)	43.19±1.40	41.48±0.61	38.11±1.16*	38.06±0.90
ADP(μM)	15.56±2.45	19.82±3.13	29.22±2.13*	19.45±3.00
AMP(nM)	25.41±7.12	42.02±12.46	97.03±11.77***	51.07±18.33
pHRest	7.07±0.01	7.10±0.05	7.02±0.02	7.06±0.03
pHIschemia	6.96±0.01	6.95±0.01	6.90±0.03	6.88±0.02
Mb (nmol/g)	0.034±0.002	0.028±0.005	0.031±0.002	0.035±0.002
Hb (nmol/g)	0.031±0.002	0.032±0.003	0.037±0.002	0.048±0.009

Data for ATP and total creatine (Cr) are from HPLC, Mb and Hb are from SDS-PAGE analysis, and all other values were calculated from MR spectra. Mean ± SEM. n = 3–9.

^*p<0.05,

^**p<0.01,

^***p<0.001 relative to young control;

^#p<0.05,

^##p<0.001 relative to age-matched control.