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A model for reciprocal regulation of B. burgdorferi surface lipoproteins by BosR and RpoS. During transition from the tick to the mammal, B. burgdorferi surface lipoproteins that are primarily expressed in the tick are repressed by BosR whereas those primarily expressed in the mammal are activated by RpoS. The interdependence of these two seemingly parallel pathways may be dictated, in part, by outer membrane homeostasis (see text for details).
