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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: J Antibiot (Tokyo). 2013 May 29;67(1):127–132. doi: 10.1038/ja.2013.50

Figure 1.

Figure 1

Proposed TAM biosynthetic pathway in S. sp. 17944, featuring the TAM hybrid PKS-NRPS and the TamI P-450 oxygenase as the key oxidative tailoring enzyme, that accounts for the formation of all TAM congeners isolated to date. TAMs 1–8 were isolated from S. sp. 17944 wild-type, while TAMs 9–13 were from S. sp. 307-9 and S. sp. SCSIO 1666 wild-type or mutant strains.