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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Lab Anim. 2013 Jun 10;47(4):257–265. doi: 10.1177/0023677213489548

Figure 2.

Figure 2

Fasting does not alter streptozotocin (STZ)-induced hyperglycemia in C57BL/6J mice. Male C57BL/6J mice were either ad libitum fed (STZ-Fed) or fasted (6 h; STZ-Fasted) at the time of multiple low dose (MLD)-STZ injections (50 mg STZ/kg body weight/day for 5 consecutive days). (a) Results of intraperitoneal glucose tolerance tests (IPGTTs) performed on treated mice 10 days after MLD-STZ. (b) Area under curve (AUC) analyses for IPGTTs. (c) Fasting (6 h) blood glucose concentrations in treated mice 10 days after MLD-STZ. (d) Results of IPGTTs performed on treated mice 20 days after MLD-STZ. (e) AUC analyses for IPGTTs. (f) Fasting (6 h) blood glucose concentrations in treated mice 20 days after MLD-STZ. (g) Results of IPGTTs performed on treated mice 20 weeks after MLD-STZ. (h) AUC analyses for IPGTTs. (i) Fasting (6 h) blood glucose concentrations in treated mice 20 days after MLD-STZ. Results are expressed as the means ± SEM. (a–f) n = 15–25 mice per group. (g–i) n = 4–5 mice per group. **P < 0.01, ***P < 0.001 compared with Control mice.