Table 1.
Long-term behavioral outcome of maternal separation depends on context.
Behavioral endophenotypes |
HOME SEP |
NOVEL SEP |
---|---|---|
Stereotypy | No change | ↑ |
Sensorimotor gating | No change | ↓ |
Working Memory | ↓ | No change |
Emotional Memory | ↓ | ↑ |
Social Interaction | No change | ↓ |
Note. Repeatedly separated pups were exposed to 8h–MS on postnatal day 3, 4 & 5 in a home (HOME-SEP; home separated) or novel context (NOVEL-SEP; novel separated) and tested in the behavioral tasks post-weaning. Rats, non-separated as pups (no history of postnatal treatments) served as controls. Based on data from Daskalakis et al., 2009a; Daskalakis, 2011; Daskalakis et al., 2012.