Figure 1.

Alignment of germline 48G7g structure (gray, PDB code: 1AJ7) with matured 48G7 (blue, PDB code: 1GAF). Somatic mutations involved in binding are highlighted in pink (G56^HV, N77^HK, and D55^LH). The remaining mutations are denoted in green (E1^HQ, E42^HK, N57^HD, G66^HD, A79^HT, S30^LN, and S34^LG). The corresponding residues in the germline structure are denoted in orange. JWJ1 is shown in its high-affinity binding conformation (cyan) with its chemical structure included below.