Table 1.
Genes up-regulated 2-fold or more in H1299 cells expressing ΔNp53:WTp53, relative to WTp53.
| GENE NAME | FOLD CHG | p VALUE | DESCRIPTION |
|---|---|---|---|
| CDKL2 | 3.6808 | 0.0085 | Kinase; development |
| CHAC1 | 2.8481 | 0.0009 | cation transport; unfolded protein response |
| TMEM229A | 2.8415 | 0.0285 | transmembrane protein; putative TF |
| DUSP5P | 2.7321 | 0.0016 | pseudogene |
| ZNF443 | 2.7007 | 0.0208 | zinc-finger protein |
| RAB27B | 2.6512 | 0.0008 | GTPase; exosome secretion pathway |
| PDE5A | 2.6027 | 0.0211 | cGMP phosphodiesterase; purine metab. |
| MARS2 | 2.4967 | 0.0095 | Met tRNA synthetase, mitochondrial |
| ZBTB42 | 2.4794 | 0.03 | linked to metabolic syndrome |
| LOC643923 | 2.4794 | 0.0351 | |
| PLK3 | 2.406 | 0.0152 | Kinase; mitosis; Insulin/PI3K/mTOR pathway |
| DUSP10 | 2.3839 | 0.0072 | Phosphatase; MAPK signaling |
| ANKRD36B | 2.308 | 0.0075 | ankyrin repeat domain |
| IRF1 | 2.2921 | 0.0003 | TF; immune function |
| IFF02 | 2.2501 | 0.0028 | intermediate filament |
| C6orf114 | 2.2449 | 0.0067 | |
| HIST1H3H | 2.2397 | 0.0191 | histone H3 |
| IRS1 | 2.214 | 0.0013 | Insulin/PI3K/mTOR pathway |
| ZNF799 | 2.2089 | 0.0138 | zinc-finger protein |
| ZBTB1 | 2.2089 | 0.0004 | cell cycle |
| CNKSR3 | 2.1685 | 0.0002 | sodium transport; MAPK pathway |
| SNX33 | 2.1685 | 0.003 | phospholipid binding |
| DOT1L | 2.1585 | 0.0057 | H3K79 methyltransferase; cell cycle/diff. |
| C3orf59 | 2.1386 | 0.0037 | |
| ZNF354B | 2.1238 | 0.0138 | zinc-finger protein |
| JMY | 2.1092 | 0.0045 | p53 cofactor; cell motility |
| MAP3K1 | 2.1092 | 0.0047 | Kinase; Insulin signaling; differentiation |
| ANKZF1 | 2.0849 | 0.0032 | binds p97 AAA ATPase |
| DHRS13 | 2.0801 | 0.0296 | glucose dehydrogenase |
| VLDLR | 2.0801 | 0.0013 | FA metabolism |
| SNORD44 | 2.0801 | 0.0044 | snoRNA |
| SEPTIN6 | 2.0705 | 0.0011 | cytokinesis; GTPase |
| DENND3 | 2.0658 | 0.002 | GTP-GDP exchange; reg. MAPK signaling |
| P2RY1 | 2.061 | 0.0441 | ATP/ADP-gated receptor |
| WHAMML1 | 2.0562 | 0.0089 | pseudogene |
| LRCH1 | 2.0515 | 0.0094 | CHO transporter |
| CYBRD1 | 2.0467 | 0.0148 | heme binding/iron uptake; reductase |
| LNX2 | 2.042 | 0.0017 | ligand of numb protein X; Notch signaling |
| HIST1H2BF | 2.0373 | 0.0084 | histone H2B |
| ANGPTL4 | 2.0373 | 0 | glucose/FA metab; mitochondrial function |
| BHLHE41 | 2.0326 | 0.0039 | TF; circadian rhythm; differentiation |
| PLEKHF1 | 2.0326 | 0.0263 | phosphatidyl-inositol signaling |
| ANKRD36 | 2.0279 | 0.002 | ankyrin repeat domain |
| MGC16384 | 2.0232 | 0.0072 | |
| PTCH1 | 2.0232 | 0.0007 | sonic hedgehog receptor; Insulin signaling |
| FGF5 | 2.0232 | 0.0165 | MAPK/insulin signaling; differentiation |
| FAT4 | 2.0139 | 0.0016 | cell-cell adhesion |
| NFIL3 | 2.0046 | 0.02 | TF; circadian rhythm |