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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Semin Radiat Oncol. 2013 Oct;23(4):296–305. doi: 10.1016/j.semradonc.2013.05.004

Figure 1.

Figure 1

Association between 18F-FDG-PET pSUVmax and survival in patients with resected non—small cell lung cancer. Several metagenes were associated with this imaging parameter that related to cell cycle regulation, proliferation, death, and self-recognition. Individual genes associated with pSUVmax were LY6E (encodes a protein that may be involved in cellular differentiation43), RNF149 (encodes a E3 ubiquitin-protern ligase that ubiquitinates the oncogene BRAF f or proteosomal degradation44) , MCM6 (encodes a DNA helicase45), and FAP (encodes or Fibroblast activation protein alpha, a membrane-bound gelatinase involved in cell invasion and motility46). (Data reproduced with permission Nair et al.27)