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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Semin Radiat Oncol. 2013 Oct;23(4):296–305. doi: 10.1016/j.semradonc.2013.05.004

Figure 2.

Figure 2

Key results from gene expression analysis of patients with locally advanced cervix cancer treated with chemoradiotherapy. (A) Unsupervised clustering of expression of 31 genes identified in a training dataset consisting of 78 patients with variable DCE-MRI-derived Abrix scores that was associated with treatment outcome. The clustering reveals a significant split by Abrix value in an independent and validation cohort (46 patients) (B). (C) In the same set of 46 patients, the signature for low expression reveals better prognosis. This independent validation is an important step toward a truly beneficial imaging biomarker as therapeutic intervention to reduce hypoxia may prove valuable in the subset with low Abrix score. (Data reproduced with permission from Halle et al.31) (Color version of figure is available online.)