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Kinetic Properties of Pim1 toward Selected Peptides.
| Peptide No. | Sequencea | kcat (s−1) | KM (μM) | kcat/KM (M−1s−1) |
|---|---|---|---|---|
| 1 | KYRHPTNMYY | 7.8 ± 0.4 | 410 ± 43 | 19000 |
| 2 | RYRHPTGMYY | 14 ± 1 | 16 ± 2 | 870000 |
| 3 | AYRHPTGMYY | >800 | 960 | |
| 4 | RYAHPTGMYY | >600 | 1200 | |
| 5 | AYAHPTGMYY | ND | ND | ND |
| 6 | RYRDPTGMYY | 1.8 ± 0.1 | 1300 ± 53 | 1400 |
| 7 | RYRHPTPMYY | 2.9 ± 0.1 | 200 ± 26 | 14000 |
| 8 | RYRHPTRMYY | 7.5 ± 0.1 | 24 ± 2 | 310000 |
All peptides contain an N-terminal acetyl group and a C-terminal amide.
ND, no detectable activity.
