Table 1. Plasma levels of 11 proteins associate with PD age at onset.

11 out of 96 proteins screened showed nominal correlations between plasma levels and PD age at onset (nominal p< 0.05) in linear regression models with age (at time of plasma draw) and gender as covariates. The direction of association for each protein is shown, as well as the significance of association (p-value) for the specific analyte. MIP-1 beta = Macrophage inflammatory protein 1 beta. IL18 = Interleukin 18. CRP= C-reactive protein. CgA = Chromogranin A. MMP9=matrix metalloproteinase 9. IgM=Immunoglobulin M.

	Plasma Protein	Direction	P-value
1	MIP1-Beta	−	<0.001	***
2	Apolipoprotein A1	+	0.001	***
3	IL18	−	0.002	**
4	CRP	−	0.003	**
5	CgA	−	0.016	*
6	Prolactin	+	0.020	*
7	MMP9	−	0.028	*
8	IgM	+	0.038	*
9	Complement3	−	0.042	*
10	TenascinC	−	0.042	*
11	SerumAmyloidP	−	0.047	*