Table 3.

Potential channels through which antiretroviral therapy may reduce the stigma of HIV ^†

	HIV symptom burden	Physical Health Summary score	Mental Health Summary score
Effect of cumulative treatment duration on the putative mediator, χ2 value (P-value)	11.9 (<0.001)	6.4 (<0.001)	7.2 (<0.001)
Association between internalized stigma and lagged values of the putative mediator, adjusted incidence rate ratio (95% confidence interval)	1.53 (1.30–1.80)	0.87 (0.79–0.97) ‡	0.79 (0.73–0.85)
Effect of cumulative treatment duration on internalized stigma, after adjusting for lagged values of the putative mediator, χ2 value (P-value)	12.0 (0.68)	18.7 (0.23)	12.1 (0.67)

^†Each cell represents an estimate derived from a separate regression model. All regression models included statistical adjustment for baseline age, sex, educational attainment, marital status, household asset wealth, CD4+ T-cell count, year of cohort entry, and time since HIV diagnosis.

^‡Estimate rate ratio reflects a 10-point change in the value of the putative mediator.