Table 1.

Factors required for sorting endosome-to-Golgi transport of STx.

Factor	Function	Reference
Clathrin	Coat	[23], [21]
Retromer	Presumptive coat; senses/ induces membrane curvature
SNX1		[35]
Vps26		[36]
Vps35		[37]
Epsin R	Clathrin adaptor	[23]
RME-8	DnaJ protein; retromer and Hsc70-interacting partner; proposed to link retromer to Hsc70	[37]
Hsc-70	Clathrin uncoating ATPase; RME-8 interacting protein; proposed to uncoat clathrin from endosome tubules	[37]
Hrs	ESCRT-0 subunit; clathrin and retromer interacting protein; proposed to compete with RME-8 for retromer binding	[37]
Dynamin	Membrane scission	[21]
EHD3	Eps15 homology domain protein; Knockdown alters SNX1 localization.	[38]
Rabenosyn-5	EDH3 interacting protein; Rab4/5 effector; knockdown alters SNX1localization.	[38]
GPP130	Endosomal receptor	[5]
OCRL1	PI(4,5)P2 5-phosphatase; clathrin interacting protein	[39]
Rab6a’	small GTPase	[40], [41]
Rab11	small GTPase	[42]
Cdc42	GTPase	[26]
ARHGAP21	Cdc42 GTPase activating protein	[26]
Arl1	small GTPase	[48]
Golgin97	Tether, Arl1 effector	[48]
Golgin245	Tether, Arl1 effector	[47]
GCC185	Tether	[49]
Syntaxin6,Syntaxin16, Vti1a, Vamp3/4	SNARE complex	[40]
Syntaxin5, Ykt6, GS15, GS28	SNARE complex	[50]
Microtubules	Cytoskeletal component	[34]
Actin	Cytoskeletal component	[26]
Dynein	Motor	[34]
Cholesterol	Microdomain organization	[43]
V-ATPase	Proton pump	[44]
p38	Kinase	[45]
PKCδ	Kinase	[46]