Table 3.
Levels of cytokines tested in the LPS, LPS + GOH, and LPS + Typ treated MKD patients' monocytes, both at 37°C and 40°C.
| Cytokine | Patients' monocytes | |||||
|---|---|---|---|---|---|---|
| 37°C | 40°C | |||||
| LPS | LPS + GOHa | LPS + Typb | LPS | LPS + GOHa | LPS + Typb | |
| IL-1β | 1235 ± 146.2 | 657 ± 283.6 | 1040 ± 73 | 494.3 ± 165.8 | 210.8 ± 93.1 | 343 ± 106.4 |
| IL-1ra | 864.6 ± 117.4 | 632.9 ± 109.6 | 808.6 ± 100.6 | 769.4 ± 47.1 | 610.6 ± 108.5 | 724.1 ± 34.2 |
| IL-2 | 114.8 ± 3.3 | 97.1 ± 9.1 | 107.2 ± 1.1 | 107.3 ± 5 | 92.7 ± 4.1 | 103.1 ± 6.1 |
| IL-4 | 13.8 ± 0.6 | 11.5 ± 1.5 | 13.6 ± 0.5 | 12.8 ± 0.9 | 10.3 ± 1.1 | 12 ± 1.3 |
| IL-6 | 21756 ± 3518 | 17544 ± 6648 | 20633 ± 3314 | 19145 ± 2204 | 12071 ± 4108 | 18614 ± 2803 |
| IL-9 | 197.3 ± 13.3 | 168.8 ± 14.5 | 190.6 ± 6.5 | 192.1 ± 8.6 | 167.7 ± 26.7 | 181.2 ± 6.5 |
| IL-12(p70) | 89.3 ± 11 | 65 ± 5.8 | 81.2 ± 4.2 | 68.9 ± 4.1 | 70 ± 2 | 69.3 ± 5.8 |
| IL-15 | 185.4 ± 5.3 | 166.3 ± 8.9 | 177.6 ± 4.6 | 176.3 ± 3.2 | 168.8 ± 6.4 | 176.3 ± 4.4 |
| IL-17 | 500.3 ± 11.4 | 427.1 ± 35 | 478.7 ± 22.4 | 495.6 ± 24.5 | 422.7 ± 21.8 | 465.3 ± 16.4 |
| Eotaxin | 216.5 ± 5 | 186.1 ± 16.6 | 211.2 ± 3.2 | 205.9 ± 11.2 | 187.6 ± 8.2 | 201 ± 11.6 |
| FGF-basic | 262.2 ± 2.2 | 231.4 ± 13.1 | 250.2 ± 6.2 | 251.1 ± 10.5 | 220.5 ± 8.1 | 242.2 ± 7.6 |
| IFN-γ | 324.3 ± 10.3 | 270.5 ± 34.7 | 310.6 ± 13.6 | 308.6 ± 15.7 | 244.6 ± 26.4 | 288.8 ± 16.9 |
| IP-10 | 146.2 ± 5.8 | 125.7 ± 14.2 | 145.7 ± 6.4 | 131.3 ± 3.2 | 113.8 ± 10.5 | 129.7 ± 7.6 |
| MIP-1α | 8980 ± 1899 | 5308 ± 2213 | 8306 ± 1780 | 8234 ± 963.1 | 4675 ± 1792 | 7854 ± 1155 |
| PDGF-BB | 129.6 ± 3 | 107.6 ± 8.6 | 123.2 ± 8.2 | 112.7 ± 2.7 | 97.4 ± 11.2 | 107.9 ± 5.2 |
| VEGF | 116.3 ± 11.5 | 96.4 ± 8.6 | 115.2 ± 10.1 | 106.4 ± 5.8 | 67.8 ± 13.7 | 112.9 ± 8.8 |
Values are expressed as mean ± SEM, in pg/mL; ageraniol; bTipifarnib.