Figure 2.

Effect of GA on the slow and rapid components of the delayed rectifier K⁺ current in guinea pig ventricular myocytes. (a) Representative traces of the rapid (I _Kr) and slow (I _Ks) components of the delayed rectifier K⁺ channel tail currents before and after treatment with 10 μM GA and 2 μM E-4031. The effects of 1, 5, and 10 μM GA and 2 μM E-4031 on I _Ks,tail (b) and I _Kr,tail (c), normalized relative to the control current (n = 5, P < 0.05). The tail current amplitudes were differences between peak outward current and the steady state current at the end of the repolarizing voltage pulses. (*P < 0.05, **P < 0.01).