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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Phytother Res. 2012 Apr 4;26(12):1934–1941. doi: 10.1002/ptr.4652

Figure 4. Purified kavalactones do not elevate intracellular free calcium in mast cells.

Figure 4

Kavalactones at the indicated concentrations (μM) were added to Fluo-4 loaded mast cells in a standard sodium Ringer's solution containing 1mM CaCl2. Baselines were established for 25s before addition of kava extract. Light grey bars show RFU at 10s prior to compound addition (basal intensity) and dark grey bars show RFU at 200s (final attained intensity of calcium response). Vehicle controls comprised equivalent volumes of DMSO (indicated in microliters) to those used in stimuli.