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. Author manuscript; available in PMC: 2013 Sep 15.
Published in final edited form as: Biochem Soc Trans. 2013 Aug;41(4):1042–1047. doi: 10.1042/BST20130077

Table 1.

Cytokines inhibited by SOCS3*.

Cytokine Receptor Chain 1† Receptor chain 2 SOCS3 pTyr site Associated JAKs
IL-6
LIF
CNTF		 IL-6Ra
LIFR
LIFR		 gp130 pY757 JAK1, JAK2, TYK2
Leptin LepR LepR pY985 JAK2
G-CSF GCSFR GCSFR pY729 JAK1, JAK2, TYK2
*

As demonstrated by genetic deletion. See [29] for review.

†

Receptors and JAKs shown in bold contain SOCS3 binding sites