FIGURE 1.

Inhibition of TNF-α increases the proliferative potential of CD8 T lymphocytes. Long-term CD8⁺ T lymphocyte cultures from PBMC of healthy donors (n = 5) were established. At each subcultivation, Ab to TNF-α (40 ng/ml), TNF-α R1-inhibitor (10 μg/ml), or medium was added, and PD followed until replicative senescence was reached. A, Comparison of total PD in treated and untreated cultures for each donor. B, Mean number of total PD for untreated and treated cultures. DN, Donor.