Table 3.

Key neurobehavioral and neurofunctional features for 14 subjects for whom detailed data could be obtained

Subject	Breathing	GI	Language	Mood	Pain response	Reciprocity	Sleep
IS09-024	Normal	GERD	Averbal, no meaningful communication	Generally happy, with inappropriate laughter	High pain tolerance	Poor eye contact	Normal
LR11-305	Normal	Feeding difficulties in infancy	Babbles	ND	ND	No visual fixation	ND
LR11-306	ND	Normal	Averbal, no meaningful communication	ND	Normal	Diminished responses	Normal
LR11-307	Hyperventilation/hypoventilation	Constipation	Averbal, no meaningful communication	Easily agitated, with self-mutilating behaviors	High pain tolerance	Poor attention, inconsistent eye contact, no pointing	Disrupted
LR11-308	ND	ND	Averbal, no meaningful communication	Generally happy	ND	Poor eye contact	ND
LR11-309	ND	ND	Averbal vocalizations only, no meaningful communication	ND	ND	Poor visual tracking	ND
LR11-312	Normal	Slow gastric emptying, GERD, constipation	Averbal, no meaningful communication	Generally happy	ND	Poor visual awareness, limited engagement	Irregular sleep initiation and maintenance
LR11-387	Normal	Severe GERD and dysphagia, constipation	Averbal, no meaningful communication	Generally happy, occasional inappropriate laughter	High pain tolerance	Poor visual tracking	Occasionally irregular sleep maintenance
LR11-388	Normal	Mild GERD and dysphagia, constipation	Averbal, no meaningful communication	Generally happy, occasional inappropriate laughter	High pain tolerance	Poor visual tracking, does not appear to distinguish individuals	Normal
LR12-013	Breath-holding behavior	Severe GERD in infancy	Averbal, no meaningful communication	Generally happy, with inappropriate laughter	High pain tolerance	Poor eye contact in early childhood, but improving, no reciprocal play	Normal
LR12-021	Normal	Normal	Averbal, some babbling	Generally happy, with inappropriate laughter, easily excitable	High pain tolerance	Inconsistent eye contact, no reciprocal play	Very disrupted in infancy, now improving
LR12-022	Normal	Severe GERD in infancy	Has 10 consistent words, some jargon	Generally happy, with some inappropriate laughter	High pain tolerance	Eye contact emerged at 3 years, some reciprocal interactions	Normal
LR12-031	Normal	GERD in infancy, treated with medication, now resolved	Averbal, some vocalizations	Irritable until 2.5 years; now generally happy with inappropriate nocturnal laughter	Inappropriate pain response, laughs with vaccinations	Poor visual fixation and attention, avoided eye contact until age 3 years	Difficult sleep onset and maintenance
LR12-275	Normal	Normal	Some babbling	Generally happy	High pain tolerance	Poor eye contact, poor visual tracking	Difficulty with sleep onset

GERD gastroesophageal reflux disease, ND no data