Table 1.
Time-dependent effects of TS on gene expression in MSK-Leuk1 cells. Fold-differences and P values are shown at each time point. Detailed lists and annotations are provided at http://physiology.med.cornell.edu/go/smoke.
| Gene Name | Affy ID | 0.5 hr | 3 hr | 6 hr | 12 hr | 24 hr | Description | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| fold | P | fold | P | Fold | P | fold | P | fold | P | |||
| CYP1A1 | 205749_at | 13.4 | 3.3E-06 | 17.4 | 2.1E-08 | 23.4 | 1.1E-07 | 11.3 | 1.5E-06 | 14.3 | 1.0E-05 | cytochrome P450, family 1, subfamily A, polypeptide 1 |
| CYP1B1 | 202437_s_at | 8.3 | 4.2E-06 | 14.1 | 4.0E-06 | 13.5 | 1.7E-06 | 5.8 | 5.5E-06 | 6.1 | 2.1E-08 | cytochrome P450, family 1, subfamily B, polypeptide 1 |
| CYP1B1 | 202435_s_at | 8.1 | 3.8E-06 | 11.4 | 1.2E-06 | 12.1 | 1.7E-06 | 6.7 | 4.3E-05 | 6.1 | 1.2E-04 | cytochrome P450, family 1, subfamily B, polypeptide 1 |
| CYP1B1 | 202436_s_at | 7.4 | 4.3E-06 | 11.0 | 4.5E-05 | 11.2 | 5.5E-08 | 6.0 | 1.5E-06 | 5.9 | 1.7E-04 | cytochrome P450, family 1, subfamily B, polypeptide 1 |
| IL24 | 206569_at | 2.8 | 5.8E-04 | 3.4 | 4.0E-06 | 2.8 | 3.6E-04 | 3.7 | 7.9E-04 | 2.8 | 1.7E-03 | Interleukin 24 |
| PTGS2 | 1554997_a_at | 2.7 | 7.0E-03 | 3.0 | 1.0E-03 | 3.0 | 4.0E-03 | 3.1 | 2.3E-03 | 3.0 | 4.8E-04 | prostaglandin-endoperoxide synthase 2 (COX-2) |
| EREG | 205767_at | 2.1 | 1.8E-03 | 2.6 | 4.0E-06 | 2.2 | 3.8E-05 | 2.4 | 8.2E-05 | 2.0 | 1.0E-04 | Epiregulin |
| LOC151438 | 1560679_at | 2.1 | 8.7E-03 | 1.9 | 1.4E-02 | 1.5 | 3.7E-02 | 3.2 | 2.1E-02 | 5.9 | 6.8E-05 | hypothetical protein LOC151438 |
| PTGS2 | 204748_at | 2.1 | 1.2E-04 | 2.7 | 1.6E-04 | 2.4 | 2.6E-03 | 3.2 | 6.1E-04 | 2.9 | 1.5E-04 | prostaglandin-endoperoxide synthase 2 (COX-2) |
| TIPARP | 212665_at | 2.0 | 2.2E-06 | 3.0 | 9.3E-09 | 2.2 | 1.7E-06 | 2.2 | 1.5E-06 | 2.0 | 1.0E-04 | TCDD-inducible poly (ADP-ribose) polymerase |
| IL1B | 205067_at | 1.9 | 1.3E-04 | 2.2 | 3.5E-07 | 2.1 | 3.1E-06 | 2.1 | 5.5E-06 | 2.1 | 6.4E-05 | Interleukin 1, beta |
| ALDH1A3 | 203180_at | 1.9 | 1.9E-04 | 2.0 | 9.8E-09 | 2.4 | 2.8E-06 | 2.0 | 1.3E-03 | 2.8 | 2.8E-04 | Aldehyde dehydrogenase 1 family, member A3 |
| IL1R2 | 211372_s_at | 1.9 | 8.4E-06 | 1.7 | 1.9E-02 | 1.9 | 5.6E-04 | 2.9 | 2.2E-03 | 5.0 | 4.6E-04 | Interleukin 1 receptor, type II |
| IL1R2 | 205403_at | 1.8 | 1.1E-05 | 1.6 | 1.6E-02 | 1.8 | 5.2E-03 | 2.7 | 3.8E-03 | 5.3 | 6.6E-04 | Interleukin 1 receptor, type II |
| IL1B | 39402_at | 1.8 | 2.9E-05 | 2.1 | 2.1E-08 | 2.0 | 1.7E-06 | 1.9 | 5.5E-06 | 2.2 | 9.4E-05 | Interleukin 1, beta |
| IL20 | 224071_at | 1.7 | 8.3E-03 | 2.1 | 6.4E-05 | 1.8 | 4.6E-04 | 1.7 | 1.5E-02 | 1.7 | 2.7E-03 | Interleukin 20 |
| DUSP4 | 204014_at | 1.7 | 1.3E-02 | 1.6 | 2.5E-03 | 1.7 | 1.2E-04 | 2.3 | 2.3E-04 | 2.4 | 5.4E-04 | dual specificity phosphatase 4 |
| 226034_at | 1.6 | 8.6E-03 | 1.6 | 2.6E-04 | 1.5 | 3.4E-04 | 2.1 | 2.4E-03 | 2.0 | 4.4E-04 | Clone IMAGE:3881549, mRNA | |
| SERPINB2 | 204614_at | 1.6 | 2.9E-03 | 1.6 | 5.8E-04 | 1.6 | 2.4E-04 | 1.9 | 1.8E-04 | 2.5 | 1.0E-05 | serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2 |
| LOC344887 | 241418_at | 1.5 | 5.0E-02 | 3.6 | 2.9E-05 | 4.2 | 5.5E-08 | 2.6 | 8.8E-05 | 1.9 | 9.8E-04 | Similar to NmrA-like family domain containing 1 |
| MAF | 209348_s_at | −1.5 | 1.9E-04 | −1.5 | 2.7E-02 | −1.5 | 1.8E-02 | −1.7 | 2.1E-02 | −1.8 | 1.7E-03 | v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) |
| PRICKLE1 | 226069_at | −1.6 | 4.1E-02 | −1.6 | 1.2E-02 | −2.2 | 2.0E-03 | −1.6 | 2.8E-02 | −2.0 | 7.7E-04 | Prickle homolog 1 (Drosophila) |
| NAV2 | 218330_s_at | −1.7 | 3.8E-03 | −1.8 | 1.3E-02 | −1.7 | 2.0E-03 | −1.7 | 3.7E-03 | −1.8 | 1.0E-04 | Neuron navigator 2 |
| FILIP1L | 204135_at | −1.7 | 3.8E-06 | −2.1 | 7.1E-06 | −2.2 | 1.3E-05 | −2.4 | 1.9E-03 | −2.1 | 6.4E-05 | Filamin A interacting protein 1-like |
| FILIP1L | 1554966_a_at | −1.7 | 8.4E-06 | −2.2 | 6.4E-05 | −2.2 | 2.0E-06 | −2.5 | 1.5E-03 | −2.2 | 1.0E-04 | Filamin A interactiong protein 1-like |
| C10orf10 | 209183_s_at | −2.0 | 6.1E-04 | −2.3 | 1.2E-03 | −2.1 | 4.4E-05 | −2.3 | 4.3E-05 | −2.1 | 6.4E-05 | chromosome 10 open reading frame 10 |
| TNFSF10 | 202688_at | −2.0 | 8.7E-03 | −1.7 | 1.3E-02 | −2.4 | 4.2E-03 | −2.3 | 4.8E-04 | −2.4 | 1.9E-04 | tumor necrosis factor (ligand) superfamily, member 10 |