Table 2.
Treatment of MSK-Leuk1 cells with TS affected pathways related to cell proliferation, inflammation, apoptosis, coagulation and tumor suppression. P values are presented. Complete lists per time point are provided at http://physiology.med.cornell.edu/go/smoke. Generated utilizing PLAGE tool (31).
| 0.5 hr | 3 hr | 6 hr | 12 hr | 24 hr | |
|---|---|---|---|---|---|
| KEGG PATHWAYS | P(genes/path) | P(genes/path) | P(genes/path) | P(genes/path) | P(genes/path) |
| Cytokine-cytokine receptor interaction | ↑0.0025(84/257) | ↑<1E-4(86/257) | ↑9E-04(83/257) | ↑0.0008(79/257) | ↑0.0025(83/257) |
| Prostaglandin and leukotriene metabolism | ↑0.0447(15/39) | ↓0.007(15/39) | ↑0.044(15/39) | ↑0.008(15/39) | ↑0.0025(15/39) |
| Neuroactive ligand-receptor interaction | ↑0.0025(43/295) | ↓0.032(46/295) | ↓0.02(51/295) | ↑0.0025(39/295) | ↑<1E-4(46/295) |
| gamma-Hexachlorocyclohexane degradation | ↑0.0092(13/45) | ↑0.003(13/45) | ↑0.008(13/45) | ↑0.0025(11/45) | ↑0.0041(14/45) |
| Hedgehog signaling pathway | ↑0.0117(21/53) | ↑0.003(21/53) | ↓0.009(23/53) | ↑0.0025(20/53) | ↓0.0025(22/53) |
| Complement and coagulation cascades | ↑0.0025(20/69) | ↑0.003(21/69) | ↑0.008(21/69) | ↑0.0025(18/69) | ↑0.0025(19/69) |
| Porphyrin and chlorophyll metabolism | ↓0.003(16/32) | ↑0.011(16/32) | ↑0.0132(16/32) | ↑0.0203(16/32) | |
| Aminosugars metabolism | ↑0.0025(24/27) | ↓0.007(24/27) | ↑0.0349(24/27) | ↑0.0218(24/27) | |
| Jak-STAT signaling pathway | ↑0.0025(81/159) | ↑0.012(81/159) | ↑0.0025(78/159) | ↑0.0025(81/159) | |
| BIOCARTA PATHWAYS | |||||
| Msp/Ron Receptor Signaling Pathway | ↓0.0001(4/6) | ↓0.0025(5/6) | ↓0.0134(5/6) | ↓0.01(5/6) | ↓0.0025(5/6) |
| Cytokine Network | ↑0.0025(5/22) | ↑0.0025(5/22) | ↑0.0025(5/22) | ↑0.003(5/22) | ↑0.0025(5/22) |
| Regulation of hematopoiesis by cytokines | ↑0.0025(6/15) | ↑0.0025(6/15) | ↑0.0418(6/15) | ↑0.046(6/15) | ↑0.0025(6/15) |
| Cytokines and Inflammatory Response | ↑0.0025(11/29) | ↑<1E-4(11/29) | ↑0.0008(11/29) | ↑0.003(11/29 | ↑<1E-4(11/29) |
| Fibrinolysis Pathway | ↑0.0025(6/12) | ↑0.0049(6/12) | ↑0.0025(6/12) | ↑0.003(5/12) | ↑0.0044(6/12) |
| Mechanism of Acetaminophen Activity and Toxicity | ↑0.0025(3/6) | ↑0.0025(3/6) | ↑0.0025(3/6) | ↑<1E-4(3/6) | ↑0.0025(3/6) |
| Signal transduction through IL1R | ↑0.0152(28/33) | ↑0.0025(28/33 | ↑0.0095(28/33) | ↑0.003(28/33) | ↑0.0044(28/33) |
| Erythrocyte Differentiation Pathway | ↑0.0025(7/15) | ↑0.0025(7/15) | ↑0.0025(7/15) | ↑0.013(7/15) | ↑0.0044(7/15) |
| Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa | ↑0.0025(43/57) | ↑0.0197(42/57) | ↑0.013(42/57) | ↑0.0096(42/57) | |
| Cells and Molecules involved in local acute inflammatory response | ↑0.0025(7/17) | ↑0.0364(8/17) | ↓0.0169(8/17) | ↑0.0025(7/17) | |
| IL-10 Anti-inflammatory Signaling Pathway | ↑0.0025(11/13) | ↓0.0076(11/13) | ↑0.0025(11/13) | ↓0.0025(11/13) | |
| Stress Induction of HSP Regulation | ↑0.0025(12/15) | ↑0.0025(12/15) | ↑0.006(11/15) | ↓0.0044(11/15) | |
| Extrinsic Prothrombin Activation Pathway | ↑0.0393(5/13) | ↑0.0291(4/13) | ↑0.013(4/13) | ↑0.0189(4/13) | |
| p53 Signaling Pathway | ↓0.0076(13/15) | ↓0.0446(14/15) | ↓0.013(13/15 | ↓0.0025(13/15) | |