Table 3.

Genes that are differentially expressed in both the airways of human smokers and MSK-Leuk1 cells exposed to TS for 0.5–24 hr with associated P-values.

Symbol	ID	Human	0.5 hr	3hr	6hr	12 hr	24 hr	Description
		Airway	p	p	p	p	p
CYP1A1	205749_at	↑4.4E-04	↑3.3E-06	↑2.1E-08	↑1.1E-07	↑1.5E-06	↑1.0E-05	cytochrome P450, family 1, subfam. A, polypep. 1
CYP1B1	202436_s_at	↑1.7E-07	↑4.3E-06	↑4.5E-05	↑5.5E-08	↑1.5E-06	↑6.6E-04	cytochrome P450, family 1, subfam. B, polypep. 1
CYP1B1	202437_s_at	↑8.5E-08	↑4.2E-06	↑4.0E-06	↑1.7E-06	↑5.5E-06	↑2.1E-08	cytochrome P450, family 1, subfam. B, polypep. 1
GCLM	203925_at	↑1.8E-05	↑1.5E-03	↑1.3E-03	↑3.4E-04	↑1.8E-04	↑3.5E-03	glutamate-cysteine ligase, modifier subunit
TXNRD1	201266_at	↑6.0E-07	↑1.2E-02	↑2.7E-04	↑4.9E-05	↑8.8E-05	↑1.6E-03	thioredoxin reductase 1
ALDH1A3	203180_at	↑1.5E-04	↑1.9E-04	↑9.8E-09	↑2.8E-06	↑1.3E-03	↑2.8E-04	aldehyde dehydrogenase 1 family, member A3
NQO1	201468_s_at	↑2.8E-13	↑4.7E-05	↑2.3E-05	↑1.3E-06	↑6.6E-04	↑1.8E-04	NAD(P)H dehydrogenase, quinone 1
NQO1	201467_s_at	↑4.7E-12	3.2E-02	>0.05	↑9.0E-05	↑4.0E-03	↑4.8E-03	NAD(P)H dehydrogenase, quinone 1
PIR	207469_s_at	↑1.3E-12	>0.05	>0.05	↑2.8E-02	↑3.1E-02	↑3.2E-02	Pirin
AKR1C1	204151_x_at	↑1.4E-10	↓2.8E-02	>0.05	↑3.8E-03	↑1.5E-02	↑6.0E-04	aldo-keto reductase family 1, member C1
NQO1	210519_s_at	↑3.1E-14	↓4.7E-02	↑1.3E-02	↑2.0E-05	↑2.1E-03	↑3.7E-04	NAD(P)H dehydrogenase, quinone 1
AKR1C1	216594_x_at	↑1.2E-09	>0.05	>0.05	↑2.4E-04	↑8.1E-03	↑9.3E-03	aldo-keto reductase family 1, member C1
AKR1C2	211653_x_at	↑4.0E-12	>0.05	>0.05	↑9.6E-03	↑2.3E-02	↑1.6E-04	aldo-keto reductase family 1, member C2
AKR1C2	209699_x_at	↑2.5E-14	↑3.8E-02	>0.05	↑2.5E-03	>0.05	↑4.4E-04	aldo-keto reductase family 1, member C2
MMP10	205680_at	↓5.6E-04	>0.05	>0.05	↓2.2E-02	>0.05	>0.05	matrix metalloproteinase 10 (stromelysin 2)