Dose dependence of statin myotoxicity. The CK level has been plotted against daily dose for atorvastatin (Fig 1A), simvastatin (Fig 1B), and pravastatin (Fig 1C). Circles represent individual patients; diamonds represent mean CK for each dose. The Spearman correlation of CK with dose is significant for the simvastatin cases (r = 0.35, p = 0.005). The correlations are not significant for the atorvastatin cases (r = -0.08, p = 0.41) or the pravastatin cases (r = -0.02, p = 0.90).