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. 2013 Sep 12;4(3):156–166.

Table 1.

Relationships of circulating levels of analytes with blood collection parameters and select breast cancer risk factors among 302 controls, Cancer Prevention Study-II Nutrition Cohort

Characteristics N % Total Adiponectin (ng/ml) Total Insulin-like Growth Factor-1 (ng/ml) C-Reactive Protein (ng/ml) C-peptide (ng/ml)
Median p-value1 Median p-value1 Median p-value1 Median p-value1
All controls 302 13,239 99 1,801 3.9
Age (years) at blood draw
    <65 59 19.5 12,773 106 1,808 3.3
    65-69 64 21.2 11,825 109 1,597 3.8
    70-74 106 35.1 13,281 94 1,655 4.0
    75+ 73 24.2 14,015 0.08 96 0.04 1,957 0.85 4.6 0.07
Hours since last meal
    <2 156 51.7 13,273 98 1,909 4.4
    2-4 118 39.1 13,290 98 1,793 3.6
    5+ 17 5.6 11,493 0.73 114 0.52 1,741 0.88 2.6 0.01
    Unknown 11 3.6 12,115 116 708 4.8
Any alcohol consumed in 24 hours prior to blood draw
    No 216 71.5 12,616 98 1,869 4.1
    Yes 75 24.8 14,423 0.02 103 0.19 1,587 0.55 3.7 0.06
    Missing 11 3.6 12,115 116 708 4.8
Usual alcohol consumption
    Not current drinker 150 49.7 12,434 97 1,841 3.9
    <1 drink/day 113 37.4 13,397 103 1,642 4.1
    1+ drink(s)/day 22 7.3 14,010 0.46 102 0.08 1,502 0.32 3.9 0.93
    Missing 17 5.6 12,583 92 2,323 3.9
Diagnosis of diabetes
    No 273 90.4 13,303 99 1,655 3.8
    Yes 19 6.3 8,999 0.01 112 0.27 2,697 0.01 5.3 0.01
    Missing 10 3.3 13,422 74 2,359 4.4
Family history of breast cancer
    Yes 56 18.5 15,185 97 1,565 3.5
    No 246 81.5 12,493 0.005 99 0.73 1,818 0.42 4.1 0.14
Body mass index (kg/m2)
    <25 141 46.7 14,551 104 1,046 3.4
    25-<30 71 23.5 11,650 94 2,219 4.5
    ≥30 55 18.2 10,440 0.001 96 0.21 4,161 <0.001 4.6 0.02
    Missing 35 11.6 14,279 98 1,597 4.4
Weight change (lbs) from age 18 to 1997
    Loss >5 21 7.0 18,560 92 609 2.8
    Loss 5 - Gain 5 31 10.3 15,635 96 844 3.0
    Gain 6-20 50 16.6 14,263 113 1,003 3.7
    Gain 21-40 92 30.5 12,118 101 1,801 4.4
    Gain 41-60 29 9.6 9,812 112 3,024 4.0
    Gain 61+ 42 13.9 10,263 <0.001 98 0.47 4,222 <0.001 5.2 <0.001
    Missing 37 12.3 14369 96 1,830 4.4
Waist circumference (cm)
    <80 94 31.1 15,428 102 907 3.2
    80-88 67 22.2 13,273 102 1,912 3.9
    >89 116 38.4 11,185 <0.001 98 0.45 2,792 <0.001 5.1 <0.001
    Missing 25 8.3 13,278 96 1,660 4.0
Recreation physical activity (MET hours/week)
    0 18 6.0 12,835 91 1,815 5.1
    0.1-6.9 65 21.5 12,773 109 2,476 4.1
    7.0-17.5 141 46.7 13,443 97 1,601 3.9
    17.6-24.4 27 8.9 15,656 110 1,801 2.8
    ≥24.5 27 8.9 10,065 0.05 97 0.74 1,501 0.15 4.2 0.11
    Missing 24 7.9 13,909 98 1,724 3.9
1

p-value calculated using Wilcoxon rank sum test if the risk factor had two categories and using the Kruskal-Wallis test if the risk factor had three or more categories.