Table 2.
Multivariable-adjusted1 odds ratios (OR) and 95% confidence intervals (CI) of the association of biomarkers with breast cancer risk among postmenopausal women who did not use postmenopausal hormones at the time of blood collection, Cancer Prevention Study-II Nutrition Cohort
| Analytes | Case N (%) | Control N (%) | Multivariable-adjusted1 OR (95% CI) | Body Mass Index + Multivariate-adjusted1 OR (95% CI) |
|---|---|---|---|---|
| Total adiponectin (ng/ml) | ||||
| 3,896-10,095 | 97 (32.1) | 100 (33.2) | 1.00 | 1.00 |
| >10,095-15,627 | 112 (37.1) | 101 (33.4) | 1.02 (0.67, 1.55) | 1.01 (0.66, 1.53) |
| >15,627-51,376 | 93 (30.8) | 101 (33.4) | 0.81 (0.52, 1.24) | 0.84 (0.54, 1.30) |
| p for trend2 | 0.26 | 0.38 | ||
| Total insulin-like growth factor-1 (ng/ml) | ||||
| 39.4-88.5 | 93 (30.8) | 101 (33.4) | 1.00 | 1.00 |
| >88.5-114.1 | 93 (30.8) | 100 (33.2) | 0.98 (0.64, 1.51) | 1.07 (0.69, 1.66) |
| >114.1-198 | 116 (38.4) | 101 (33.4) | 1.21 (0.81, 1.82) | 1.28 (0.85, 1.93) |
| p for trend2 | 0.12 | 0.08 | ||
| C-reactive protein (ng/ml) | ||||
| 107-1,076 | 91 (30.6) | 99 (33.3) | 1.00 | 1.00 |
| >1,076-2,669 | 100 (33.7) | 99 (33.3) | 1.08 (0.71, 1.64) | 1.03 (0.67, 1.60) |
| >2,669-28,647 | 106 (35.7) | 99 (33.3) | 1.19 (0.79, 1.79) | 1.09 (0.70, 1.70) |
| p for trend2 | 0.10 | 0.16 | ||
| C-peptide (ng/ml) | ||||
| 0.90-3.09 | 82 (27.2) | 102 (33.8) | 1.00 | 1.00 |
| >3.09-5.15 | 92 (30.6) | 99 (32.8) | 1.22 (0.80, 1.85) | 1.17 (0.77, 1.80) |
| >5.15-13.55 | 127 (42.2) | 101 (33.4) | 1.63 (1.08, 2.45) | 1.51 (0.99, 2.31) |
| p for trend2 | 0.001 | 0.004 | ||
1
The conditional logistic regression models included cases and controls matched on age and race and adjusted for time from last meal to blood draw, alcohol in the 24 hours before blood draw, prior diagnosis of diabetes, and family history of breast cancer.
2
p for trend was calculated using the continuous variable.