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. Author manuscript; available in PMC: 2013 Sep 16.
Published in final edited form as: Cancer Res. 2007 Jul 15;67(14):6768–6776. doi: 10.1158/0008-5472.CAN-07-0139

Figure 4.

Figure 4

K5Cre;C/EBPαfl/fl mice display a significant increase in tumor growth rate and the rate of malignant progression. A, tumor diameter at 14 wks of TPA promotion. B, immunohistochemical staining for BrdUrd in tumors harvested 25 wks after start of TPA promotion.The BrdUrd-positive cells are represented by the dark staining nuclei. C, number of BrdUrd-positive cell layers in tumors. Tumors were matched in size between genotypes and harvested 25 wks after start of TPA promotion. Forty fields of view per tumor (12 tumors per genotype) were analyzed. Bars, SE. *, P < 0.01, Student’s t test. D, chart representing the carcinoma and carcinoma in situ incidence at 25 wks after TPA promotion. *, P = 0.059 for K5Cre;C/EBPαfl/fl mice versus control mice; §, P = 0.013 for K5Cre;C/EBPαfl/fl mice versus wild-type mice; ‡, P = 0.003 for K5Cre;C/EBPαfl/fl mice versus wild-type mice (Fisher’s exact test).