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. Author manuscript; available in PMC: 2013 Sep 16.
Published in final edited form as: Nat Chem Biol. 2013 Mar;9(3):145–153. doi: 10.1038/nchembio.1158

Figure 4. Multifaceted aaRSs scaffold proteins.

Figure 4

The three scaffold proteins that are required for the assembly of the MSC have diverse functions outside of the MSC.

TNFα: Tumor necrosis factor-alpha; IL-6: interleukin-6; GP96: 96-kDa glycoprotein; NF: neurofilament; FBP: fuse-binding protein; TRAF2: TNF receptor-associated factor 2; USP29: ubiquitin specific peptidase 29; ATM/ATR: ataxia telangiectasia mutated (ATM) and ATR (ATM and Rad3-related) protein kinases.