Table 2c.
Univariate analysis of SNPs in relation to breast cancer time-to-onset, not adjusted for multiple comparisons. We show the most significant five SNPs for African American, Hispanics, and for the meta-analysis of both, respectively, in the three sections of the chart.
| Gene | rs # | Allele | AA AF (case/control) | AA HR (CI) | AA P | AA r^2 | Hisp AF (case/control) | Hisp HR (CI) | Hisp P | Hisp r^2 | Meta HR | Meta P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| adipoq | rs1501299 | T/G | 0.31/0.36 | 0.84 (0.75,0.94) | 0.0031 | 0.99 | 0.26/0.29 | 0.9 (0.72,1.12) | 0.36 | 1 | 0.85 (0.77,0.95) | 0.0023 |
| adipor2 | chr12:1863750:D | G/GA | 0.056/0.042 | 1.36 (1.07,1.72) | 0.012 | 0.96 | 0.0074/0.0034 | 0.85 | NA | |||
| adipoq | rs6773957 | G/A | 0.48/0.45 | 1.14 (1.029,1.27) | 0.013 | 1 | 0.57/0.53 | 1.15 (0.94,1.4) | 0.17 | 1 | 1.15 (1.043,1.26) | 0.0044 |
| adipoq | rs1063538 | C/T | 0.48/0.45 | 1.14 (1.028,1.27) | 0.013 | 1 | 0.57/0.53 | 1.15 (0.94,1.4) | 0.16 | 1 | 1.14 (1.043,1.26) | 0.0046 |
| adipoq | chr3:186572864:I | CA/C | 0.48/0.45 | 1.14 (1.028,1.27) | 0.014 | 0.99 | 0.56/0.53 | 1.13 (0.93,1.38) | 0.22 | 0.98 | 1.14 (1.039,1.25) | 0.0059 |
| adipor2 | rs73041886 | C/T | 0.037/0.029 | --- | --- | 0.9 | 0.12/0.08 | 1.54 (1.13,1.1) | 0.0059 | 0.91 | --- | --- |
| adipor2 | rs73041888 | T/C | 0.037/0.029 | --- | --- | 0.9 | 0.12/0.08 | 1.54 (1.13,1.1) | 0.0059 | 0.91 | --- | --- |
| adipoq | rs1648707 | A/C | 0.48/0.46 | 1.035 (0.92,1.16) | 0.55 | 0.89 | 0.51/0.55 | 0.78 (0.64,0.95) | 0.015 | 0.95 | 0.97 (0.88,1.066) | 0.49 |
| adipoq | rs6444174 | C/T | 0.15/0.15 | 1.016 (0.88,1.18) | 0.84 | 1 | 0.05/0.03 | 1.73 (1.11,1.7) | 0.015 | 1 | 1.07 (0.93,1.23) | 0.34 |
| adipoq | rs4632532 | T/C | 0.48/0.46 | 1.034 (0.92,1.16) | 0.56 | 0.89 | 0.51/0.55 | 0.78 (0.64,0.96) | 0.016 | 0.95 | 0.97 (0.88,1.067) | 0.5 |
| adipoq | rs3774261 | G/A | 0.47/0.44 | 1.14 (1.025,1.27) | 0.015 | 1 | 0.57/0.53 | 1.15 (0.95,1.4) | 0.16 | 1 | 1.14 (1.041,1.25) | 0.0051 |
| adipor2 | rs7137757 | C/T | 0.18/0.16 | 1.15 (0.99,1.34) | 0.064 | 0.86 | 0.12/0.089 | 1.43 (1.037,1.98) | 0.029 | 0.81 | 1.2 (1.046,1.37) | 0.0093 |
| adipoq | rs3821799 | C/T | 0.46/0.43 | 1.12 (1.0052,1.24) | 0.04 | 1 | 0.54/0.51 | 1.16 (0.95,1.41) | 0.14 | 1 | 1.13 (1.027,1.24) | 0.012 |
| adipoq | rs6414520 | G/A | 0.34/0.37 | 0.88 (0.78,0.98) | 0.022 | 0.99 | 0.28/0.31 | 0.89 (0.72,1.11) | 0.31 | 0.99 | 0.88 (0.8,0.97) | 0.013 |
| adipoq | rs4686804 | A/G | 0.46/0.43 | 1.11 (1.0021,1.24) | 0.046 | 0.99 | 0.54/0.51 | 1.16 (0.95,1.41) | 0.14 | 0.99 | 1.12 (1.024,1.24) | 0.014 |
AA: African American women; Hisp: Hispanic women; Allele: allele 1/allele 2; AF: allele frequency of allele 1; HR: Hazards ratio; CI: Confidence interval; Meta: Meta-analysis; r2: Estimated imputation r2.