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SP cells in BM are depleted in diabetic mice. SP-HSCs were detected using the ‘side population’ method of analysis in (a) control, (b) short-term-diabetic and (c) long-term-diabetic mice, the last of these showing reduced progenitor cells (11 month duration of type 1 diabetes) compared with control and short-term type 1 diabetes. n=3 mice per group; representative images of three independent experiments. Ho, Höechst
