MI algorithm. An independent data monitoring committee cardiac subcommittee reviewed all patient records in the Modified Intent to Treat–As Randomized cohort in a treatment-blinded fashion. Patients were assigned an MI category according to the algorithm based on ECG criteria and chest abbreviated injury score (AIS), troponin, and CK-MB data. 2XULN, two times upper limit of normal. (Adapted from Moore EE, Moore FA, Fabian TC, et al. Human polymerized hemoglobin for the treatment of hemorrhagic shock when blood is unavailable: the USA Multicenter Trial. J Am Coll Surg 2009;208:1–13; with permission.)
Regional wall motion abnormality or ischemia on stress testing will be incorporated if available.