. Author manuscript; available in PMC: 2013 Sep 16.

Published in final edited form as: Crit Care Clin. 2009 Apr;25(2):325–Contents. doi: 10.1016/j.ccc.2009.01.002

Table 1.

Potential role of hemoglobin-based oxygen carriers in trauma care

Application	Location
Perioperative applications
Reduce allogeneic RBC transfusions	ED, angiography, OR, ICU
Attenuate transfusion immunodulation	OR, ICU
Acute hemorrhagic shock
When stored RBCs are unavailable	Field, ED, OR, ICU, remote hospital, civilian disaster, military conflict
More efficient resuscitation	Field, ED, OR, ICU
Low-volume resuscitation	Remote hospital, civilian disaster, military conflict
Regional perfusion
Enhance oxygen delivery
Ischemic reperfusion tissue/organ	OR, ICU
Inflamed tissue	OR, ICU
Ex vivo organ perfusion	Hospital, OR

Abbreviations: ED, Emergency department; OR, Operating room.