Table 6.
Systemic blood pressure
| Characteristic | As Treated (N = 714)
|
Per Protocol (N = 590)
|
||
|---|---|---|---|---|
| PolyHeme (N = 350) | Control (N = 364) | PolyHeme (N = 279) | Control (N = 311) | |
| Markedly abnormal high SBP (>180 mm Hg) | ||||
|
| ||||
| At admissiona | 6 (2) | 5 (1) | 5 (2) | 4 (1) |
|
| ||||
| At 6 h post injurya | 11 (3) | 5 (1) | 10 (4) | 4 (1) |
|
| ||||
| At admission or 6 h post inurya | 16 (5) | 10 (3) | 14 (5) | 8 (3) |
|
| ||||
| Markedly abnormal high DBP (>105 mm Hg) | ||||
|
| ||||
| At admissiona | 23 (7) | 18 (5) | 17 (6) | 14 (5) |
|
| ||||
| At 6 h post injurya | 3 (1) | 8 (2) | 3 (1) | 5 (2) |
|
| ||||
| At admission or 6 h post inurya | 26 (7) | 25 (7) | 20 (7) | 18 (6) |
|
| ||||
| SBP at admission (mm Hg)b | 115 (2) | 113 (2) | 115 (2) | 113 (2) |
|
| ||||
| SBP at 6 h post injury (mm Hg)b | 129 (2)c | 122 (2) | 129 (2)c | 122 (2) |
|
| ||||
| DBP at admission (mm Hg)b | 71 (1)c | 68 (1) | 71 (1) | 68 (1) |
|
| ||||
| DBP at 6 h post injury (mm Hg)b | 73 (1)c | 66 (1) | 73 (1)c | 66 (1) |
Abbreviations: DPB, Diastolic blood pressure.
a
Values are expressed as n (%); percentages are based on the number of patients in each treatment group divided by number of patients who had nonmissing values.
b
Values are expressed as mean (SE).
c
P<.05 compared with Control.
Data from Moore EE, Moore FA, Fabian TC, et al. Human polymerized hemoglobin for the treatment of hemorrhagic shock when blood is unavailable: the USA Multicenter Trial. J Am Coll Surg 2009;208:1–13.