Figure 4.

When injected into the dorsal striatum, GR7-scr and GR7-short hairpin RNA (shRNA) showed similar ethanol intake and ethanol preference in the test with a two-bottle free-choice paradigm. GR7-shRNA rats show normal voluntary ethanol consumption and preference. (a) Both groups showed a similar increase in ethanol consumption with increasing concentrations of ethanol up to 10% v/v ethanol. (b) Preference for ethanol over water and (c) total fluid intake were similar between GR7-scr and GR7-shRNA groups. Data are presented as the mean±SEM. ^*p<0.05, the difference between the indicated group (two-way analysis of variance, Bonferroni's post hoc test).