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. 2012 Jul 11;38(11):2109–2119. doi: 10.1038/npp.2012.122

Figure 6.

Figure 6

Lentiviral vector (LV) injection into the nucleus accumbens (NAcc), of GR7-short hairpin RNA (shRNA) but not GR7-scr, induces knockdown of mGluR7 mRNA expression in the NAcc. (a) Histological representation of injection placements in the NAcc. The distance anterior to bregma (in millimeters) is indicated. (b) Rats were stereotaxically microinjected with GR7-scr or GR7-shRNA into the NAcc. GR7-shRNA decreased mGluR7 mRNA expression in the NAcc but not in the dorsal striatum (DS). (c) Mean blood ethanol concentrations (BEC) of GR7-scr and GR7-shRNA injected rats into the NAcc following a single injection with ethanol (2.5 g/kg body weight, intraperitoneal). Blood was collected from the tail vein at various times after injection and analyzed to determine the ethanol concentration. Values represent the mean±SEM. *p<0.01, the difference between the indicated group (two-way analysis of variance, Bonferroni's post hoc test). GAPDH, glyceraldehyde-3-phosphate dehydrogenase.